Wellbutrin (bupropion) is a prescription medicine used for major depression, seasonal affective disorder, and to help people stop smoking. It works differently from common antidepressants — it mainly boosts norepinephrine and dopamine. That makes it a useful option when other drugs cause fatigue or sexual side effects.
Wellbutrin comes in several forms: immediate-release, sustained-release (SR), and extended-release (XL). Your doctor picks the type and dose based on your condition and how you tolerate the drug. People often choose Wellbutrin for low energy, low motivation, or when sexual side effects on SSRIs are a problem. Doctors also prescribe it to reduce nicotine cravings during quitting.
Common side effects are dry mouth, trouble sleeping, headache, sweating, and nausea. Most side effects are mild and fade in a few weeks. A rare but serious risk is seizures, especially at higher doses or in people with seizure disorders, eating disorders, or heavy alcohol use. That’s why your doctor will ask about medical history before starting treatment.
Take Wellbutrin exactly as prescribed. If you take the XL version, take it once daily in the morning to lower the chance of insomnia. Don’t crush or chew extended-release tablets. If you miss a dose, take it as soon as you remember but don’t double up.
Tell your doctor about any history of seizures, eating disorders like bulimia or anorexia, recent heavy alcohol use, or any current medications. Avoid starting Wellbutrin within two weeks of stopping an MAOI, and don’t mix them without medical guidance. Be careful with other drugs that raise seizure risk or stimulants.
Watch your mood during the first few weeks. Antidepressants can sometimes increase anxiety or cause worsening mood or suicidal thoughts, especially in young adults. If you notice sudden mood changes, new agitation, or suicidal thinking, get help right away.
Practical tips that help most people: take the pill in the morning, keep a medication list to share with all providers, avoid binge drinking, and use a pillbox or phone reminder to stay on schedule. If sexual side effects from other antidepressants pushed you to try Wellbutrin, discuss realistic expectations — it helps many people, but results vary.
If Wellbutrin stops working or causes troubling side effects, don’t stop on your own. Call your prescriber to adjust the dose or try a different treatment. Your doctor can guide safe changes and monitor progress. For reliable articles and patient stories about antidepressants and medication choices, check our site’s guides and reader experiences.
How long before you feel better? Many people notice some improvement in energy and focus within one to two weeks, but full antidepressant effects usually take four to six weeks. For quitting smoking, craving reduction starts in days but full benefit comes with behavioral support. Typical starting doses are 150 mg once daily for XL or 150 mg twice daily for SR, but follow your prescriber's plan. If you are pregnant or breastfeeding, discuss risks and benefits—your doctor will help.
Wellbutrin, also known as bupropion, is a popular antidepressant with some unique benefits and side effects. This article explains how it works, what makes it different, and shares tips for using it effectively. You'll learn about common dosages, pros and cons, and real-life experiences. Get facts on Wellbutrin's uses and what to expect if you're considering or already taking it.