Mefenamic Acid: Uses, Risks, and What You Need to Know

When you’re dealing with painful periods, muscle aches, or inflammation, mefenamic acid, a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain and swelling. Also known as Ponstan, it’s one of the few NSAIDs specifically approved for menstrual cramps in many countries. Unlike acetaminophen, which just dulls pain, mefenamic acid targets the root cause—chemicals in your body that trigger inflammation and cramping. It’s not a cure, but it can turn unbearable days into manageable ones.

But it’s not harmless. Mefenamic acid carries the same risks as other NSAIDs: stomach ulcers, kidney strain, and increased heart risks if used long-term or in high doses. People with a history of ulcers, asthma triggered by painkillers, or heart disease should avoid it unless a doctor says otherwise. It also interacts with blood thinners, SSRIs, and even some blood pressure meds. If you’re on multiple drugs, check for interactions before taking it. It’s not just about the pill—it’s about what else is in your system.

What makes mefenamic acid stand out? It’s one of the few NSAIDs that’s been studied specifically for heavy menstrual bleeding and severe cramps. For many women, it works better than ibuprofen or naproxen for this purpose. But it’s not the only option. Alternatives like tranexamic acid or hormonal birth control can help too, especially if the problem is hormonal. And if you’re using it for other types of pain—like backaches or arthritis—you might be better off with something less risky over time.

Some people take mefenamic acid without realizing it’s in combination products. Always check the label. Mixing it with other NSAIDs—even over-the-counter ones—can lead to overdose without you noticing. And because it’s not always the first choice in the U.S., many aren’t aware of how powerful it is. It’s not a mild pain reliever. It’s a targeted tool, and like any tool, it can cause harm if used carelessly.

You’ll find posts here that dig into how mefenamic acid compares to other painkillers, what side effects really happen (not just the ones listed on the box), and how to manage them. There are also guides on drug interactions, especially with mood stabilizers and antibiotics, because these combinations can turn dangerous fast. We cover real cases—not theory—so you know what to watch for and when to call your doctor.

Whether you’re using it for cramps, joint pain, or something else, the goal isn’t just to feel better today. It’s to stay safe tomorrow. The information below gives you the facts you need to make that call—with no fluff, no marketing, just what matters for your health.