Domperidone is a medication people use to ease nausea, vomiting, and slow stomach emptying. Some doctors also prescribe it off-label to help with low breast milk supply. It can work well, but it isn’t risk-free. This page gives straightforward facts about what domperidone does, typical dosing, common side effects, and simple safety tips so you can talk with your doctor prepared.
Domperidone blocks dopamine receptors in parts of the body that control gut movement and the hormone prolactin. By doing that, it helps the stomach move food faster and can boost milk production in some people. The effect on hormones is why you might see breast-related side effects. The gut action is why it can stop nausea and vomiting for many patients.
Adults commonly take 10 mg three times a day before meals. Some prescribers give 20 mg doses, but total daily limits and personal health factors matter. Many guidelines recommend using the lowest effective dose for the shortest time possible. If you miss a dose, take it when you remember unless it’s almost time for the next one. Don’t double up.
Keep it away from strong CYP3A4 inhibitors like ketoconazole, clarithromycin, and some HIV drugs. Those can raise domperidone levels and increase the chance of heart issues. Also avoid mixing with other drugs that lengthen the heart’s QT interval, such as certain antipsychotics and some antibiotics.
Store domperidone in a cool, dry place and keep it out of reach of children. If you buy meds online, use a reputable pharmacy and a valid prescription. Counterfeit or improperly dosed products can be dangerous.
If you plan to use domperidone for breastfeeding support, discuss risks and benefits with a clinician. Some countries restrict its use for lactation and recommend cardiac monitoring in higher-risk patients.
Watch for side effects. Common ones include dry mouth, stomach cramps, headache, and dizziness. Because domperidone can raise prolactin, you might see breast tenderness, milk production, or menstrual changes. These can be reversible when the drug stops.
Serious but rare effects include irregular heartbeat, fainting, or sudden weakness. If you feel palpitations, faint, or have chest discomfort, stop the drug and seek medical help. People with known heart disease, low potassium, or liver problems need extra caution and often a different treatment choice.
Before starting domperidone, tell your provider about all medicines, supplements, and any heart or liver issues. Ask whether an ECG or blood tests are needed. If the drug works, check in regularly. If it doesn’t help within a short trial or causes worrying symptoms, your provider will suggest alternatives.
Questions for your doctor: Is domperidone right given my heart history? What dose and for how long? Do I need tests while taking it? Keep those questions handy when you call or visit your clinic.
In a sweeping safety revision, the MHRA has updated the guidelines on domperidone usage, limiting its recommendation to treating nausea and vomiting. The update emphasizes minimal effective dosages and advisories for patients with heart or liver conditions, aiming to mitigate heart-related risks.